{"product_id":"nad-resveratrol-supplement","title":"NAD+ \u0026 Resveratrol Supplement with Quercetin – Healthy Aging Formula","description":"\u003cp\u003eNAD+ and resveratrol are usually sold separately, and quercetin is usually an afterthought. This supplement puts all three in one serving: 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), 250mg of Quercetin Dihydrate, and 150mg of Japanese Knotweed extract standardized to 98% resveratrol. The idea is simple. How much NAD+ your cells actually have depends on three things: how much you supply, how fast it's broken down, and whether the proteins that use it can do their job. Each ingredient covers one of them.\u003c\/p\u003e\n\n\u003ch2\u003eWhy NAD+ and Resveratrol Are Paired\u003c\/h2\u003e\n\u003cp\u003eResveratrol got famous in the 2000s as a sirtuin activator. Sirtuins are a family of seven proteins involved in cellular maintenance, and SIRT1 is the best known. What took longer to appreciate is that sirtuins run on NAD+. Without enough of it, activating them doesn't do much. That's the real case for the pairing: resveratrol for SIRT1 activity, NAD+ for the fuel it depends on.\u003c\/p\u003e\n\u003cp\u003eThe human evidence for resveratrol alone is mixed. Trials in postmenopausal women using 150mg a day found improvements in cognitive performance, while other studies found little effect. This formula delivers about 147mg a day. For the longer version of this story, read our article on \u003ca href=\"\/blogs\/news\/nad-and-resveratrol\"\u003eNAD+ and resveratrol\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eQuercetin and the CD38 Problem\u003c\/h2\u003e\n\u003cp\u003eCD38 is the enzyme that breaks NAD+ down, and it gets busier with age. In adipose tissue, CD38 expression is about 2.5 times higher in older adults.\u003c\/p\u003e\n\u003cp\u003eQuercetin is the most studied natural CD38 inhibitor. Escande and colleagues (2013) measured its inhibition in cell-free and cellular systems and found dose-dependent increases in NAD+ inside cells. This formula uses the dihydrate form from Sophora japonica flower buds, which dissolves in water more easily than the anhydrous form. More on that in \u003ca href=\"\/blogs\/news\/can-you-take-quercetin-with-nad-the-science-of-synergy-explained-1\"\u003ecan you take quercetin with NAD+\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eWhy Direct NAD+ Plus a CD38 Inhibitor\u003c\/h2\u003e\n\u003cp\u003eThis formula supplies NAD+ directly, and it's fair to say what that means: part of an oral NAD+ dose is broken down in the small intestine before it's absorbed, and your cells use those pieces to rebuild NAD+. That's one reason we didn't rely on NAD+ alone. Quercetin works on breakdown and resveratrol on how NAD+ gets used, so the formula covers supply and breakdown together.\u003c\/p\u003e\n\n\u003ch2\u003eWhat the Human Evidence Shows\u003c\/h2\u003e\n\u003cp\u003eIn clinical trials of oral NAD+ supplementation, blood NAD+ rises within about two weeks, and the effect holds with continued daily use. People who notice a difference usually describe steadier energy and focus between week 2 and week 4.\u003c\/p\u003e\n\u003cp\u003eA lot of the most talked-about NAD+ research was done in animals, and we don't think animal results should be sold as human ones. What we offer is a daily healthy aging formula with sensible doses of the three compounds that research on NAD+ availability points to, with every amount printed on the label.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Take It\u003c\/h2\u003e\n\u003cp\u003eTwo capsules each morning with water. NAD+ metabolism follows a daily rhythm, with mitochondrial energy production peaking during daytime hours, so morning makes more sense than night. Take it with breakfast if your stomach is sensitive, and give it 8 weeks.\u003c\/p\u003e\n\u003cp\u003eIf you take prescription medication, have a medical condition, are undergoing medical treatment, or are pregnant or breastfeeding, talk to your doctor first. Our \u003ca href=\"\/blogs\/news\/nad-side-effects\"\u003eNAD+ side effects\u003c\/a\u003e guide covers the details.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCan you take NAD+ and resveratrol together?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes. That's the combination in this capsule, and the two work on connected parts of the same pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan you take quercetin with NAD+?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes. Quercetin is included specifically to slow NAD+ breakdown by CD38.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow long does one bottle last?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e30 days. There are 60 capsules and the serving is two a day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMorning or night?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMorning, for the circadian reasons above.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Soleu Nutrition","offers":[{"title":"Default Title","offer_id":58610543034699,"sku":"SN-NAD-60C-L","price":49.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/5557\/9723\/files\/NAD_principal.jpg?v=1784498848","url":"https:\/\/soleunutrition.com\/products\/nad-resveratrol-supplement","provider":"Soleu Nutrition","version":"1.0","type":"link"}