{"title":"NAD+ ICP","description":null,"products":[{"product_id":"nad-supplement-for-women","title":"NAD+ for Women 45+ – Resveratrol \u0026 Quercetin, Menopause Support","description":"\u003cp\u003eThis NAD+ supplement for women is built for the years when energy and focus stop behaving the way they used to. Each two-capsule serving gives you 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), 250mg of Quercetin Dihydrate, and 150mg of Japanese Knotweed extract standardized to 98% resveratrol, which works out to about 147mg of resveratrol a day. That last number is the reason this page exists. It sits right next to the 150mg daily dose used in a series of clinical trials run specifically in postmenopausal women. It contains no hormones, and it doesn't replace anything your doctor recommends. It's daily menopause support for cellular energy and focus, with the doses printed on the label.\u003c\/p\u003e\n\n\u003ch2\u003eWhy Energy and Focus Change After 45\u003c\/h2\u003e\n\u003cp\u003eTwo things happen at once in midlife, and most women feel them before they can name them.\u003c\/p\u003e\n\u003cp\u003eThe first is NAD+. It's a coenzyme your cells use in more than 500 enzymatic reactions, including making ATP inside your mitochondria. Cleveland Clinic's overview of the research puts the drop at roughly 50% between ages 40 and 60. The second is an enzyme called CD38, whose job is to break NAD+ down. Its activity climbs with age (in adipose tissue, CD38 expression is about 2.5 times higher in older adults than in younger ones). So supply goes down while breakdown goes up.\u003c\/p\u003e\n\u003cp\u003ePerimenopause adds its own layer. Estrogen helps regulate blood flow, including blood flow to the brain, and many women notice the afternoon fog and the dips in stamina around the same time their cycles start to change. A supplement can't undo that transition. What it can do is support the cellular side of your energy while your body adjusts.\u003c\/p\u003e\n\n\u003ch2\u003eThe Resveratrol Dose Studied in Postmenopausal Women\u003c\/h2\u003e\n\u003cp\u003eResearchers at the University of Newcastle in Australia ran the RESHAW trials (Resveratrol for Healthy Ageing in Women) using 75mg of resveratrol twice a day, 150mg daily, in postmenopausal women aged 45 to 85.\u003c\/p\u003e\n\u003cp\u003eIn the 14-week pilot with 80 women, resveratrol increased cerebrovascular responsiveness by 17% compared with placebo and improved verbal memory and overall cognitive performance (Nutrients, 2017). The larger follow-up, 129 women over 12 months, confirmed the improvement in overall cognitive performance (Nutrients, 2020). The same 24-month program also reported better scores for chronic pain, menopause-related quality of life and general well-being (Menopause, 2020), along with small gains in bone density at the lumbar spine and femoral neck (Journal of Bone and Mineral Research, 2020).\u003c\/p\u003e\n\u003cp\u003eTwo honest caveats. Those trials tested resveratrol on its own, not this three-ingredient formula. And this product delivers about 147mg of resveratrol, not exactly 150mg. We think the match is close enough to be worth telling you about, and not close enough to promise you the same results.\u003c\/p\u003e\n\n\u003ch2\u003eWhat Each Ingredient Does in This NAD+ Supplement for Women\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eNAD+ 500mg\u003c\/strong\u003e supplies the coenzyme itself. Part of an oral dose is broken down in the gut into precursors your body can reuse, which is one reason the formula doesn't rely on NAD+ alone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuercetin Dihydrate 250mg\u003c\/strong\u003e, from Sophora japonica flower buds, is the most studied natural CD38 inhibitor. A 2013 study in Diabetes measured its CD38 inhibition in cell systems and linked it to higher NAD+ inside cells. In plain terms, it works on the drain rather than the tap.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResveratrol (98%) from Japanese Knotweed root\u003c\/strong\u003e is included for the reasons above, and because SIRT1, the best known of the sirtuin proteins, can only work when NAD+ is available.\u003c\/p\u003e\n\u003cp\u003eThe capsules are vegetable HPMC. Other ingredients are microcrystalline cellulose, brown rice flour, olive oil, silicon dioxide and magnesium stearate. No artificial colors and no nicotinic acid, so no niacin flush.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Take It\u003c\/h2\u003e\n\u003cp\u003eTake two capsules in the morning with breakfast and a glass of water. Food helps if your stomach is sensitive in the first week or two. Give it at least 30 days before you judge it, and ideally 8 weeks, which is the evaluation window most NAD+ trials use. Consistency matters more than the exact time of day.\u003c\/p\u003e\n\n\u003ch2\u003eTalk to Your Doctor First If This Applies to You\u003c\/h2\u003e\n\u003cp\u003eResveratrol is a phytoestrogen, a plant compound that can interact with estrogen receptors. If you take prescription medication, have a hormone-sensitive or other medical condition, are undergoing medical treatment, or are pregnant or breastfeeding, talk to your doctor before starting.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eIs NAD+ good for women?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNAD+ levels fall with age in both sexes, and most of the people searching for NAD+ support in the US are women between 45 and 64. What's specific to women in this formula is the resveratrol dose, which is the one studied in postmenopausal women.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIs this a menopause treatment?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNo. It's a dietary supplement that supports energy, focus and cellular health during perimenopause and menopause. It isn't intended for any medical condition, and it isn't a substitute for medical care.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow long until I notice a difference?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBlood NAD+ rises within about two weeks in clinical trials. People who notice a change in energy usually describe it somewhere between week 2 and week 4. Give it 8 weeks before deciding.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWill it make me flush?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNo. Flushing comes from nicotinic acid, and there's none in this formula.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Soleu Nutrition","offers":[{"title":"Default Title","offer_id":58610539397451,"sku":"SN-NAD-60C-W","price":49.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/5557\/9723\/files\/NAD_principal.jpg?v=1784498848"},{"product_id":"nad-supplement-for-men","title":"NAD+ for Men 40+ with Resveratrol \u0026 Quercetin – Daily Energy \u0026 Focus","description":"\u003cp\u003eThis NAD+ supplement for men is for the guy in his 40s or 50s who used to get through the afternoon without a third coffee and now doesn't. Each two-capsule serving has 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), 250mg of Quercetin Dihydrate and 150mg of Japanese Knotweed extract standardized to 98% resveratrol. There's no caffeine and no stimulant in it. It supports the cellular side of energy, the part coffee doesn't touch, and the doses are on the label so you can check them.\u003c\/p\u003e\n\n\u003ch2\u003eWhy Energy Drops After 40\u003c\/h2\u003e\n\u003cp\u003eNAD+ is the coenzyme your mitochondria need to turn food into ATP. It's involved in more than 500 enzymatic reactions, and Cleveland Clinic's overview of the research puts the decline at roughly 50% between ages 40 and 60.\u003c\/p\u003e\n\u003cp\u003eSupply isn't the whole story. An enzyme called CD38 breaks NAD+ down, and its activity rises with age. If you train hard, there's a third draw on the same pool: hard exercise raises the activity of PARP enzymes, which also run on NAD+. That's why men who lift, run or ride often feel the afternoon slump earlier than their sedentary friends of the same age.\u003c\/p\u003e\n\n\u003ch2\u003eWhat's Inside and Why\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eNAD+ 500mg.\u003c\/strong\u003e The coenzyme itself. Some of an oral dose is split into smaller pieces in the gut and rebuilt inside cells, which is why the formula doesn't stop at NAD+.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuercetin Dihydrate 250mg\u003c\/strong\u003e from Sophora japonica flower buds. It's the most researched natural CD38 inhibitor; a 2013 study tied its CD38 inhibition to higher NAD+ inside cells. The dihydrate form dissolves in water better than the cheaper anhydrous form.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResveratrol 98%\u003c\/strong\u003e from Japanese Knotweed root, about 147mg a day. It's included for SIRT1, a sirtuin protein that can't work without NAD+. The human data on resveratrol and sirtuins is mixed, and we'd rather tell you that than oversell it.\u003c\/p\u003e\n\n\u003ch2\u003eWhat to Expect, and What Not To\u003c\/h2\u003e\n\u003cp\u003eIn clinical trials, blood NAD+ rises within about two weeks of daily supplementation. People who notice a change describe steadier energy through the afternoon and clearer focus, usually between week 2 and week 4. Some notice nothing dramatic, which is why 8 weeks is the fair test.\u003c\/p\u003e\n\u003cp\u003eWhat it won't do: it won't give you a buzz. If you're looking for a pre-workout feeling, this isn't that.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Take It\u003c\/h2\u003e\n\u003cp\u003eTwo capsules in the morning with water, with breakfast if your stomach is sensitive. It fits alongside most training stacks, including creatine, protein and electrolytes. Take it daily, training day or not.\u003c\/p\u003e\n\n\u003ch2\u003eWho Should Ask a Doctor First\u003c\/h2\u003e\n\u003cp\u003eIf you take prescription medication, have a medical condition, are undergoing medical treatment, or are pregnant or breastfeeding, talk to your doctor before taking this or any new supplement.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHow long does one bottle last?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e30 days. There are 60 capsules and the serving is two a day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan I take it with pre-workout or creatine?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes, for most people. It has no caffeine, so it won't stack with the stimulant in your pre-workout.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWill it make me flush like niacin?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNo. Flushing comes from nicotinic acid, and this formula has none.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Soleu Nutrition","offers":[{"title":"Default Title","offer_id":58610541494603,"sku":"SN-NAD-60C-M","price":49.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/5557\/9723\/files\/NAD_principal.jpg?v=1784498848"},{"product_id":"nad-resveratrol-supplement","title":"NAD+ \u0026 Resveratrol Supplement with Quercetin – Healthy Aging Formula","description":"\u003cp\u003eNAD+ and resveratrol are usually sold separately, and quercetin is usually an afterthought. This supplement puts all three in one serving: 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), 250mg of Quercetin Dihydrate, and 150mg of Japanese Knotweed extract standardized to 98% resveratrol. The idea is simple. How much NAD+ your cells actually have depends on three things: how much you supply, how fast it's broken down, and whether the proteins that use it can do their job. Each ingredient covers one of them.\u003c\/p\u003e\n\n\u003ch2\u003eWhy NAD+ and Resveratrol Are Paired\u003c\/h2\u003e\n\u003cp\u003eResveratrol got famous in the 2000s as a sirtuin activator. Sirtuins are a family of seven proteins involved in cellular maintenance, and SIRT1 is the best known. What took longer to appreciate is that sirtuins run on NAD+. Without enough of it, activating them doesn't do much. That's the real case for the pairing: resveratrol for SIRT1 activity, NAD+ for the fuel it depends on.\u003c\/p\u003e\n\u003cp\u003eThe human evidence for resveratrol alone is mixed. Trials in postmenopausal women using 150mg a day found improvements in cognitive performance, while other studies found little effect. This formula delivers about 147mg a day. For the longer version of this story, read our article on \u003ca href=\"\/blogs\/news\/nad-and-resveratrol\"\u003eNAD+ and resveratrol\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eQuercetin and the CD38 Problem\u003c\/h2\u003e\n\u003cp\u003eCD38 is the enzyme that breaks NAD+ down, and it gets busier with age. In adipose tissue, CD38 expression is about 2.5 times higher in older adults.\u003c\/p\u003e\n\u003cp\u003eQuercetin is the most studied natural CD38 inhibitor. Escande and colleagues (2013) measured its inhibition in cell-free and cellular systems and found dose-dependent increases in NAD+ inside cells. This formula uses the dihydrate form from Sophora japonica flower buds, which dissolves in water more easily than the anhydrous form. More on that in \u003ca href=\"\/blogs\/news\/can-you-take-quercetin-with-nad-the-science-of-synergy-explained-1\"\u003ecan you take quercetin with NAD+\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eWhy Direct NAD+ Plus a CD38 Inhibitor\u003c\/h2\u003e\n\u003cp\u003eThis formula supplies NAD+ directly, and it's fair to say what that means: part of an oral NAD+ dose is broken down in the small intestine before it's absorbed, and your cells use those pieces to rebuild NAD+. That's one reason we didn't rely on NAD+ alone. Quercetin works on breakdown and resveratrol on how NAD+ gets used, so the formula covers supply and breakdown together.\u003c\/p\u003e\n\n\u003ch2\u003eWhat the Human Evidence Shows\u003c\/h2\u003e\n\u003cp\u003eIn clinical trials of oral NAD+ supplementation, blood NAD+ rises within about two weeks, and the effect holds with continued daily use. People who notice a difference usually describe steadier energy and focus between week 2 and week 4.\u003c\/p\u003e\n\u003cp\u003eA lot of the most talked-about NAD+ research was done in animals, and we don't think animal results should be sold as human ones. What we offer is a daily healthy aging formula with sensible doses of the three compounds that research on NAD+ availability points to, with every amount printed on the label.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Take It\u003c\/h2\u003e\n\u003cp\u003eTwo capsules each morning with water. NAD+ metabolism follows a daily rhythm, with mitochondrial energy production peaking during daytime hours, so morning makes more sense than night. Take it with breakfast if your stomach is sensitive, and give it 8 weeks.\u003c\/p\u003e\n\u003cp\u003eIf you take prescription medication, have a medical condition, are undergoing medical treatment, or are pregnant or breastfeeding, talk to your doctor first. Our \u003ca href=\"\/blogs\/news\/nad-side-effects\"\u003eNAD+ side effects\u003c\/a\u003e guide covers the details.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCan you take NAD+ and resveratrol together?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes. That's the combination in this capsule, and the two work on connected parts of the same pathway.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan you take quercetin with NAD+?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eYes. Quercetin is included specifically to slow NAD+ breakdown by CD38.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow long does one bottle last?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e30 days. There are 60 capsules and the serving is two a day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMorning or night?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMorning, for the circadian reasons above.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Soleu Nutrition","offers":[{"title":"Default Title","offer_id":58610543034699,"sku":"SN-NAD-60C-L","price":49.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/5557\/9723\/files\/NAD_principal.jpg?v=1784498848"},{"product_id":"oral-nad-capsules","title":"NAD+ 500mg Daily Capsules – Needle-Free, with Resveratrol \u0026 Quercetin","description":"\u003cp\u003eIf you've looked into NAD+ injections or IV drips and balked at the price, the needles, or the two hours in a clinic chair, this is the oral option. Two capsules a day give you 500mg of NAD+ (Nicotinamide Adenine Dinucleotide), plus 250mg of Quercetin Dihydrate and 150mg of Japanese Knotweed extract standardized to 98% resveratrol. One bottle lasts 30 days. We'll be straight with you from the start: oral NAD+ and IV NAD+ are not the same thing, and this page explains how they differ so you can decide.\u003c\/p\u003e\n\n\u003ch2\u003eCapsules vs IV vs Injections: What Actually Differs\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eRoute and dose.\u003c\/strong\u003e An IV puts NAD+ straight into your bloodstream, often 250mg to 1,000mg over one to several hours. An oral dose goes through digestion first, and part of it is broken down in the small intestine into precursors that your cells use to rebuild NAD+ (PMC10240123). You get a smaller, slower effect, taken every day instead of in bursts.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCost.\u003c\/strong\u003e Published clinic prices for a single NAD+ IV session run from about $150 to $600 in many US markets and up to $1,000 or more in cities like New York, Los Angeles and Miami. A month of these capsules costs $49.95.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSide effects.\u003c\/strong\u003e Most of the NAD+ side effects people describe online (chest tightness, nausea, cramping during the drip) come from infusions that run too fast. Capsule trials report far milder effects, mostly mild stomach upset. Our guide to \u003ca href=\"\/blogs\/news\/nad-side-effects\"\u003eNAD+ side effects\u003c\/a\u003e compares the two in detail.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConvenience.\u003c\/strong\u003e No appointment, no needle, no recovery time. You take it with breakfast.\u003c\/p\u003e\n\n\u003ch2\u003eWhy the Capsule Adds Quercetin and Resveratrol\u003c\/h2\u003e\n\u003cp\u003eBecause an oral dose is smaller and slower, it helps to protect what you get. Quercetin is the most studied natural inhibitor of CD38, the enzyme that breaks NAD+ down, and CD38 activity rises with age. Resveratrol supports SIRT1, a sirtuin protein that depends on NAD+ to function. Together they work on how long NAD+ lasts and how it's used, not just how much you put in.\u003c\/p\u003e\n\n\u003ch2\u003eWhat Oral NAD+ Can and Can't Do\u003c\/h2\u003e\n\u003cp\u003eIn clinical trials of oral NAD+ precursors, blood NAD+ rises within about two weeks and stays up with daily use. People who notice a difference usually describe steadier energy and focus between week 2 and week 4.\u003c\/p\u003e\n\u003cp\u003eWhat it can't do is reproduce the high blood levels of an infusion. If a doctor has recommended IV NAD+ for a specific reason, a capsule isn't a replacement for that conversation. If you were considering IV mainly for everyday energy and healthy aging, a daily capsule is a reasonable, far cheaper place to start.\u003c\/p\u003e\n\n\u003ch2\u003eHow to Take It\u003c\/h2\u003e\n\u003cp\u003eTwo capsules in the morning with water, with food if your stomach is sensitive. Give it 8 weeks. If you're already doing IV sessions, ask the clinic whether taking capsules between sessions makes sense for you.\u003c\/p\u003e\n\u003cp\u003eIf you take prescription medication, have a medical condition, are undergoing medical treatment, or are pregnant or breastfeeding, talk to your doctor before taking this or any new supplement.\u003c\/p\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDo NAD+ capsules work the same as an IV?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNo. They're different routes with different blood levels. Capsules give a smaller, steady daily supply; an IV gives a large dose all at once.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy choose oral NAD+?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePrice, convenience and tolerability. A month of capsules costs less than most single IV sessions, and there's no needle involved.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan I use capsules between IV sessions?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMany people do. Ask your provider, especially if you take other medications.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWill I feel a rush like during an IV?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNo. There's no rush and no flushing; the formula has no nicotinic acid.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n","brand":"Soleu Nutrition","offers":[{"title":"Default Title","offer_id":58610547687755,"sku":"SN-NAD-60C-O","price":49.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1037\/5557\/9723\/files\/NAD_principal.jpg?v=1784498848"}],"url":"https:\/\/soleunutrition.com\/collections\/nad-icp-hidden.oembed","provider":"Soleu Nutrition","version":"1.0","type":"link"}